Journal of the American College of Cardiology
Volume 48, Issue 8 , Pages 1666-1671 , 17 October 2006

Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function

  • Berenice Cortés, BS

      Affiliations

    • Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • The first two authors contributed equally to this work.
    • ,
  • Isabel Núñez, MD

      Affiliations

    • Unitat de Lípids, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Spain
    • The first two authors contributed equally to this work.
    • ,
  • Montserrat Cofán, PhD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • ,
  • Rosa Gilabert, MD, PhD

      Affiliations

    • Unitat de Lípids, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Spain
    • ,
  • Ana Pérez-Heras, RD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • ,
  • Elena Casals, MD, PhD

      Affiliations

    • Centre de Diagnòstic Biològic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.
    • ,
  • Ramón Deulofeu, PhD

      Affiliations

    • Centre de Diagnòstic Biològic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.
    • ,
  • Emilio Ros, MD, PhD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • Corresponding Author InformationReprint requests and correspondence: Dr. Emilio Ros, Unitat de Lípids, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.

Received 22 March 2006 ,Revised 31 May 2006 ,Accepted 6 June 2006.

  • Image Result

    Mean flow-mediated dilation before and 4 h after fatty meals with added olive oil (squares) or walnuts (triangles). Vertical bars indicate SE. Time–period interaction: p = 0.006 by repeated-measures a

    Mean flow-mediated dilation before and 4 h after fatty meals with added olive oil (squares) or walnuts (triangles). Vertical bars indicate SE. Time–period interaction: p = 0.006 by repeated-measures analysis of variance.

  • Image Result
    Changes from baseline of variables related to glycemic control and triglycerides after the test meals in study groups. Vertical bars are 95% confidence interval. No group, time, or period interactions

    Changes from baseline of variables related to glycemic control and triglycerides after the test meals in study groups. Vertical bars are 95% confidence interval. No group, time, or period interactions were observed for any of the variables by repeated-measures analysis of variance. FFA = free fatty acids; HC = hypercholesterolemia group.

  • Image Result
    Changes from baseline of inflammation and endothelial activation markers and asymmetric dimethylarginine (ADMA) after the test meals in study groups. Vertical bars are 95% confidence interval. *Greate

    Changes from baseline of inflammation and endothelial activation markers and asymmetric dimethylarginine (ADMA) after the test meals in study groups. Vertical bars are 95% confidence interval. *Greater reduction after the walnut meal compared with the olive oil meal (time–period interaction: p = 0.033 by repeated-measures analysis of variance). sICAM-1 = soluble intercellular adhesion molecule 1; sTNF = soluble tumor necrosis factor; sVCAM-1 = soluble vascular cell adhesion molecule 1.

 Supported by an unrestricted grant and provision of walnuts by the California Walnut Commission (CWC), Sacramento, California, and by grants from the Spanish Ministry of Health (FIS 00/0992, RT/C03-01, RT/G03-140). Berenice Cortés was supported by a grant from Fundación Carolina, Madrid, Spain. Dr. Ros serves on the Scientific Advisory Board of the CWC.

PII: S0735-1097(06)01912-7

doi: 10.1016/j.jacc.2006.06.057

Journal of the American College of Cardiology
Volume 48, Issue 8 , Pages 1666-1671 , 17 October 2006

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