Journal of the American College of Cardiology
Volume 48, Issue 8 , Pages 1666-1671 , 17 October 2006

Acute Effects of High-Fat Meals Enriched With Walnuts or Olive Oil on Postprandial Endothelial Function

  • Berenice Cortés, BS

      Affiliations

    • Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • The first two authors contributed equally to this work.
  • ,
  • Isabel Núñez, MD

      Affiliations

    • Unitat de Lípids, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Spain
    • The first two authors contributed equally to this work.
  • ,
  • Montserrat Cofán, PhD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
  • ,
  • Rosa Gilabert, MD, PhD

      Affiliations

    • Unitat de Lípids, Institut Clínic de Malalties Digestives i Metabòliques, Barcelona, Spain
  • ,
  • Ana Pérez-Heras, RD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
  • ,
  • Elena Casals, MD, PhD

      Affiliations

    • Centre de Diagnòstic Biològic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.
  • ,
  • Ramón Deulofeu, PhD

      Affiliations

    • Centre de Diagnòstic Biològic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.
  • ,
  • Emilio Ros, MD, PhD

      Affiliations

    • Secció d’Ecografia, Centre de Diagnòstic per l’Imatge, Barcelona, Spain
    • Corresponding Author InformationReprint requests and correspondence: Dr. Emilio Ros, Unitat de Lípids, Hospital Clínic, Villarroel 170, 08036 Barcelona, Spain.

Received 22 March 2006 ,Revised 31 May 2006 ,Accepted 6 June 2006.

References 

  1. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003;23:168–175
  2. Hanson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
  3. Cooke JP. Asymmetrical dimethylarginine (The über marker?). Circulation. 2004;109:1813–1819
  4. Sydowa K, Münzel T. ADMA and oxidative stress. Atheroscler Suppl. 2003;4:41–51
  5. West SG. Effect of diet on vascular reactivity: an emerging marker for vascular risk. Curr Atheroscler Rep. 2001;3:446–455
  6. de Koning EJP, Rabelink TJ. Endothelial function in the postprandial state. Atheroscler Suppl. 2002;3:11–16
  7. Plotnick GD, Corretti MC, Vogel RA, Hesslink R, Wise JA. Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. J Am Coll Cardiol. 2003;41:1744–1749
  8. Vogel RA, Corretti MC, Plotnick GD. The postprandial effect of components of the Mediterranean diet on endothelial function. J Am Coll Cardiol. 2000;36:1455–1460
  9. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent vasoactivity following a single high-fat meal. JAMA. 1997;278:1682–1686
  10. Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects (A randomized crossover trial). Circulation. 2004;109:1609–1614
  11. Zambón D, Sabaté J, Muñoz S, et al. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women (A randomized crossover trial). Ann Intern Med. 2000;132:538–546
  12. Otto ME, Svatikova A, de Mattos Barretto RB, et al. Early morning attenuation of endothelial function in healthy humans. Circulation. 2004;109:2507–2510
  13. Gaenzer H, Sturm W, Neumayr G, et al. Pronounced postprandial lipemia impairs endothelium-dependent dilation of the brachial artery in men. Cardiovasc Res. 2001;52:509–516
  14. Packard CJ, Shepherd J. Lipoprotein heterogeneity and apolipoprotein B metabolism. Arterioscler Thromb Vasc Biol. 1997;17:3542–3556
  15. Maggi FM, Raselli S, Grigore L, Redaelli L, Fantappie S, Catapano AL. Lipoprotein remnants and endothelial dysfunction in the postprandial phase. J Clin Endocrinol Metab. 2004;89:2946–2950
  16. Sanderson P, Olthof M, Grimble RF, et al. Dietary lipids and vascular function: UK Food Standards Agency workshop report. Br J Nutr. 2004;91:491–500
  17. West SWG, Hecker KD, Mustad VA, et al. Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes. Diabetologia. 2005;48:113–122
  18. Bae JH, Schwemmer M, Lee IK, Park KR, Kim KY, Bassenge E. Postprandial hypertriglyceridemia-induced endothelial dysfunction in healthy subjects is independent of lipid oxidation. Int J Cardiol. 2003;87:259–267
  19. Steinberg FM, Guthrie NL, Villablanca AC, Kumar K, Murray MJ. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr. 2003;78:123–130
  20. Burdge GC, Calder PC. Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?. Br J Nutr. 2005;93:3–9
  21. De Caterina R, Liao JK, Libby P. Fatty acid modulation of endothelial activation. Am J Clin Nutr. 2000;71(Suppl):213S–223S
  22. Zhao G, Etherton TD, Martin KR, West SG, Gillies PJ, Kris-Etherton PM. Dietary α-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women. J Nutr. 2004;134:2991–2997

 Supported by an unrestricted grant and provision of walnuts by the California Walnut Commission (CWC), Sacramento, California, and by grants from the Spanish Ministry of Health (FIS 00/0992, RT/C03-01, RT/G03-140). Berenice Cortés was supported by a grant from Fundación Carolina, Madrid, Spain. Dr. Ros serves on the Scientific Advisory Board of the CWC.

PII: S0735-1097(06)01912-7

doi: 10.1016/j.jacc.2006.06.057

Journal of the American College of Cardiology
Volume 48, Issue 8 , Pages 1666-1671 , 17 October 2006