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Journal of the American College of Cardiology
Volume 49, Issue 25
, Pages 2379-2393
, 26 June 2007
Role of Endothelial Shear Stress in the Natural History of Coronary Atherosclerosis and Vascular Remodeling: Molecular, Cellular, and Vascular Behavior
References
- . Atherosclerosis—an inflammatory disease. N Engl J Med. 1999;340:115–126
- . Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695
- . Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulators. Arterioscler Thromb Vasc Biol. 2004;24:12–22
- . Hemodynamic shear stress and its role in atherosclerosis. JAMA. 1999;282:2035–2042
- Prediction of sites of coronary atherosclerosis progression: in vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior. Curr Opin Cardiol. 2003;18:458–470
- . Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann N Y Acad Sci. 2000;902:230–239
- . The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest. 2005;85:9–23
- . Arterial wall shear and distribution of early atheroma in man. Nature. 1969;223:1159–1160
- . Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res. 1990;66:1045–1066
- . Pulsatile flow and atherosclerosis in the human carotid bifurcation (Positive correlation between plaque location and low oscillating shear stress). Arteriosclerosis. 1985;5:293–302
- . Fluid wall shear stress measurements in a model of the human abdominal aorta: oscillatory behavior and relationship to atherosclerosis. Atherosclerosis. 1994;110:225–240
- . Plaque-prone hemodynamics impair endothelial function in pig carotid arteries. Am J Physiol Heart Circ Physiol. 2006;290:H2320–H2328
- Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique. Blood. 2005;106:3691–3698
- . Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction. Atherosclerosis. 1999;143:27–40
- Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation. 2003;108:438–444
- Relationship between neointimal thickness and shear stress after Wallstent implantation in human coronary arteries. Circulation. 2001;103:1740–1745
- Does shear stress modulate both plaque progression and regression in the thoracic aorta? (Human study using serial magnetic resonance imaging). J Am Coll Cardiol. 2005;45:846–854
- Low endothelial shear stress (ESS) is responsible for the heterogeneity and severity of coronary atherosclerotic plaques: an in-vivo IVUS natural history study (abstr). Circulation. 2006;114:II23
- Low endothelial shear stress (ESS) predicts the development of high-risk coronary atherosclerotic plaques: a correlative IVUS and histopathology natural history study (abstr). J Am Coll Cardiol. 2007;49(Suppl A):334A
- Low endothelial shear stress (ESS) leads to expansive remodeling of atherosclerotic coronary subsegments: an in-vivo followup IVUS study (abstr). J Am Coll Cardiol. 2007;49(Suppl):335A
- Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation. 2006;113:2744–2753
- . Arterial wall response to ex vivo exposure to oscillatory shear stress. J Vasc Res. 2005;42:535–544
- Regions of low endothelial shear stress are sites where coronary plaque progress and vascular remodeling occurs in humans: an in-vivo serial study. Eur Heart J. 2007;28:705–710
- Extension of increased atherosclerotic wall thickness into high shear stress regions is associated with loss of compensatory remodeling. Circulation. 2003;108:17–23
- Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition. Circulation. 2001;104:91–96
- . McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clincal Principles. 5th edition. London: A Hodder Arnold Publication; 2005;
- The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat Clin Pract Cardiovasc Med. 2005;2:401–407
- . Fundamentals of Fluid Mechanics. Canada: John Wiley & Sons; 1990;
- . Determination of in vivo velocity and endothelial shear stress patterns with phasic flow in human coronary arteries: a methodology to predict progression of coronary atherosclerosis. Am Heart J. 2002;143:931–939
- . Toward the quiescent coronary plaque. J Am Coll Cardiol. 1993;22:1228–1241
- . Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque. Curr Opin Cardiol. 2000;15:430–440
- . Assessment of vascular wall shear stress and implications for atherosclerotic disease. Int J Cardiol. 2006;113:12–18
- Large variations in absolute wall shear stress levels within one species and between species. Atherosclerosis. 2006;Dec 11;[e-pub ahead of print]
- . Blood flow in arteries. Annu Rev Fluid Mech. 1997;79:399–434
- Spatial and phasic oscillation of non-Newtonian wall shear stress in human left coronary artery bifurcation: an insight to atherogenesis. Coron Artery Dis. 2006;17:351–358
- . Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler Thromb Vasc Biol. 1999;19:1825–1834
- . Haemodynamic factors and the important role of local low static pressure in coronary wall thickening. Int J Cardiol. 2002;86:27–40
- . Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force. Arterioscler Thromb Vasc Biol. 1998;18:677–685
- . Molecular basis of the effects of shear stress on vascular endothelial cells. J Biomech. 2005;38:1949–1971
- . Molecular mechanisms of the vascular responses to haemodynamic forces. J Intern Med. 2006;259:381–392
- A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature. 2005;437:426–431
- . Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment. Embo J. 2001;20:4639–4647
- . Role of integrins in endothelial mechanosensing of shear stress. Circ Res. 2002;91:769–775
- . Signal transduction of mechanical stresses in the vascular wall. Hypertension. 1998;32:338–345
- Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction. Annu Rev Physiol. 1997;59:527–549
- Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature. Proc Natl Acad Sci U S A. 2004;101:14871–14876
- . Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flow. Physiol Genomics. 2002;9:27–41
- Fluid shear stress and the vascular endothelium: for better and for worse. Prog Biophys Mol Biol. 2003;81:177–199
- . Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med. 2006;259:351–363
- Increased blood flow causes coordinated upregulation of arterial eNOS and biosynthesis of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol. 2006;290:H786–H793
- Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol. 2001;91:1574–1581
- . Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells. Arterioscler Thromb Vasc Biol. 1998;18:686–692
- . Interaction between wall shear stress and circumferential strain affects endothelial cell biochemical production. J Vasc Res. 2000;37:147–157
- Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002;22:76–81
- . Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol. 2003;83:131–151
- Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products. Circ Res. 2004;95:780–788
- . Spatial comparison between wall shear stress measures and porcine arterial endothelial permeability. Am J Physiol Heart Circ Physiol. 2004;286:H1916–H1922
- . Temporal gradients in shear, but not spatial gradients, stimulate endothelial cell proliferation. Circulation. 2001;103:2508–2513
- . Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation. 2000;101:2450–2453
- . Ultrastructural studies on macromolecular permeability in relation to endothelial cell turnover. Atherosclerosis. 1995;118:89–104
- Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation. Circ Res. 2003;93:1225–1232
- Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. Am J Physiol Heart Circ Physiol. 2003;285:H2290–H2297
- . The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress. Circ Res. 2005;97:637–644
- . Inflammation in atherosclerosis. Nature. 2002;420:868–874
- . The subendothelial extracellular matrix modulates NF-kappaB activation by flow: a potential role in atherosclerosis. J Cell Biol. 2005;169:191–202
- . NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?. J Clin Invest. 2001;107:255–264
- IkappaBalpha-dependent regulation of low-shear flow-induced NF-kappa B activity: role of nitric oxide. Am J Physiol Cell Physiol. 2003;284:C1039–C1047
- Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003;17:1648–1657
- . The leukocyte response to fluid stress. Proc Natl Acad Sci U S A. 1997;94:5338–5343
- Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol. 2002;22:405–411
- . Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells. J Surg Res. 2002;102:13–21
- Endothelial cells inhibit flow-induced smooth muscle cell migration: role of plasminogen activator inhibitor-1. Circulation. 2001;103:597–603
- . Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. J Vasc Surg. 2003;37:182–190
- . Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis. Arterioscler Thromb Vasc Biol. 2004;24:399–404
- . Studies on TGF-beta 1 gene expression in the intima of the human aorta in regions with high and low probability of developing atherosclerotic lesions. Mod Pathol. 1995;8:478–482
- . Elastic lamina defects are an early feature of aortic lesions in the apolipoprotein E knockout mouse. J Vasc Res. 2005;42:237–246
- Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005;96:368–375
- A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis (A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association). Circulation. 1995;92:1355–1374
- . Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–1275
- . Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress (Role of c-Myc). J Biol Chem. 2003;278:32994–32999
- . Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation model. Circulation. 2000;102:2861–2866
- . Flow regulation of 72-kD collagenase IV (MMP-2) after experimental arterial injury. Circulation. 1998;98:157–163
- Quantitation and localization of matrix metalloproteinases and their inhibitors in human carotid endarterectomy tissues. Arterioscler Thromb Vasc Biol. 2006;26:2351–2358
- Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. Arterioscler Thromb Vasc Biol. 2006;26:340–346
- . Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994;94:2493–2503
- . Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002;90:251–262
- . Atherosclerosis and proteinase activation. Cardiovasc Res. 2006;69:625–635
- . Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo. Arterioscler Thromb Vasc Biol. 2002;22:765–771
- Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation. 2006;113:98–107
- Destabilizing role of cathepsin S in murine atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2006;26:851–856
- . Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:1359–1366
- . Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Biol. 2004;24:650–657
- . Laminar shear stress inhibits cathepsin L activity in endothelial cells. Arterioscler Thromb Vasc Biol. 2006;26:1784–1790
- . Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex. J Biol Chem. 2003;278:49134–49144
- . Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside. Cytokine Growth Factor Rev. 2006;17:225–233
- Interferon-gamma induces Fas trafficking and sensitization to apoptosis in vascular smooth muscle cells via a PI3K- and Akt-dependent mechanism. Am J Pathol. 2006;168:2054–2063
- . Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J Immunol. 1996;156:3469–3477
- Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression. Arterioscler Thromb Vasc Biol. 2002;22:975–982
- Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation. 2004;110:2032–2038
- . Shear stress-induced endothelial cell migration involves integrin signaling via the fibronectin receptor subunits alpha(5) and beta(1). Arterioscler Thromb Vasc Biol. 2002;22:69–75
- Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase. Circ Res. 2004;95:773–779
- . Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol. 2006;26:1423–1430
- . Detection and treatment of vulnerable plaques and vulnerable patients: novel approaches to prevention of coronary events. Circulation. 2006;114:2390–2411
- . Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res. 1994;74:852–860
- Differential regulation of protease activated receptor-1 and tissue plasminogen activator expression by shear stress in vascular smooth muscle cells. Circ Res. 1998;83:1027–1034
- Impact of coronary artery remodeling on clinical presentation of coronary artery disease: an intravascular ultrasound study. J Am Coll Cardiol. 2001;37:63–69
- . Extent and direction of arterial remodeling in stable versus unstable coronary syndromes: an intravascular ultrasound study. Circulation. 2000;101:598–603
- . Structural and hemodynamic response of peripheral arteries of macaque monkeys to atherogenic diet. Arteriosclerosis. 1985;5:336–346
- . Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–1375
- Remodeling characteristics of minimally diseased coronary arteries are consistent along the length of the artery. Am J Cardiol. 2006;97:13–16
- Paradoxical increase in lumen size during progression of coronary atherosclerosis: observations from the REVERSAL trial. Atherosclerosis. 2006;189:229–235
- . Strain-dependent vascular remodeling: the “Glagov phenomenon” is genetically determined. Circulation. 2004;110:220–226
- . Expansive remodeling is a response of the plaque-related vessel wall in aortic roots of apoE-deficient mice: an experiment of nature. Arterioscler Thromb Vasc Biol. 2003;23:257–262
- . Contribution of inadequate arterial remodeling to the development of focal coronary artery stenoses (An intravascular ultrasound study). Circulation. 1997;95:1791–1798
- Correlation of coronary arterial remodeling determined by intravascular ultrasound with angiographic diameter reduction of 20% to 60%. Am J Cardiol. 2003;92:141–145
- Arterial remodeling in the left coronary system: the role of high-density lipoprotein cholesterol. J Am Coll Cardiol. 1999;34:760–767
- Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation. 2001;103:934–940
- . Arterial remodeling (Mechanisms and clinical implications). Circulation. 2000;102:1186–1191
- Determinants of arterial wall remodeling during lipid-lowering therapy: serial intravascular ultrasound observations from the Reversal of Atherosclerosis with Aggressive Lipid Lowering Therapy (REVERSAL) trial. Circulation. 2006;113:2826–2834
- Terminology for high-risk and vulnerable coronary artery plaques (Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece). Eur Heart J. 2004;25:1077–1082
- From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664–1672
- Coronary artery remodelling is related to plaque composition. Heart. 2006;92:388–391
- Intravascular ultrasound analysis of infarct-related and non-infarct-related arteries in patients who presented with an acute myocardial infarction. Circulation. 2003;107:2889–2893
- . Relationship between coronary artery remodeling and plaque vulnerability. Circulation. 2002;105:939–943
- Expansive arterial remodeling is associated with increased neointimal macrophage foam cell content: the murine model of macrophage-rich carotid artery lesions. Circulation. 2002;105:2686–2691
- Relation of arterial geometry to luminal narrowing and histologic markers for plaque vulnerability: the remodeling paradox. J Am Coll Cardiol. 1998;32:655–662
- Beyond restenosis: five-year clinical outcomes from second-generation coronary stent trials. Circulation. 2004;110:1226–1230
- . Vulnerable atherosclerotic plaque: a multifocal disease. Circulation. 2003;107:2072–2075
- Plaque composition and its relationship with acknowledged shear stress patterns in coronary arteries. J Am Coll Cardiol. 2006;47:884–885
- . Shear-stress-mediated arterial remodeling in atherosclerosis: too much of a good thing?. Circulation. 2006;113:2787–2789
- Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med. 2004;350:1495–1504
- True 3-dimensional reconstruction of coronary arteries in patients by fusion of angiography and IVUS (ANGUS) and its quantitative validation. Circulation. 2000;102:511–516
- In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. Coron Artery Dis. 2006;17:533–543
- In-vivo accuracy of geometrically correct three-dimensional reconstruction of human coronary arteries: is it influenced by certain parameters?. Coron Artery Dis. 2006;17:545–551
- Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans. Catheter Cardiovasc Interv. 2003;60:67–78
- . New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques. J Am Coll Cardiol. 2006;47:C2–C6
PII: S0735-1097(07)01220-X
doi: 10.1016/j.jacc.2007.02.059
© 2007 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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Journal of the American College of Cardiology
Volume 49, Issue 25
, Pages 2379-2393
, 26 June 2007
