Journal of the American College of Cardiology
Volume 52, Issue 8 , Pages 644-651 , 19 August 2008

Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol

  • Amy J. Sehnert, MD

      Affiliations

    • CardioDx, Inc., Palo Alto, California
    • Corresponding Author InformationReprint requests and correspondence: Dr. Amy J. Sehnert, CardioDx, Inc., 2500 Faber Place, Palo Alto, California 94303.
    • ,
  • Susan E. Daniels, PhD

      Affiliations

    • CardioDx, Inc., Palo Alto, California
    • ,
  • Michael Elashoff, PhD

      Affiliations

    • CardioDx, Inc., Palo Alto, California
    • ,
  • James A. Wingrove, PhD

      Affiliations

    • CardioDx, Inc., Palo Alto, California
    • ,
  • Christopher R. Burrow, MD

      Affiliations

    • CardioDx, Inc., Palo Alto, California
    • ,
  • Benjamin Horne, PhD

      Affiliations

    • Departments of Cardiology and Cardiovascular Research, Intermountain Medical Center, University of Utah, Salt Lake City, Utah
    • ,
  • Joseph B. Muhlestein, MD, FACC

      Affiliations

    • Departments of Cardiology and Cardiovascular Research, Intermountain Medical Center, University of Utah, Salt Lake City, Utah
    • ,
  • Mark Donahue, MD

      Affiliations

    • Department of Medicine and Cardiology, Duke University Medical Center, Durham, North Carolina
    • ,
  • Stephen B. Liggett, MD

      Affiliations

    • Departments of Medicine and Physiology, University of Maryland School of Medicine, Baltimore, Maryland.
    • ,
  • Jeffrey L. Anderson, MD, FACC

      Affiliations

    • Departments of Cardiology and Cardiovascular Research, Intermountain Medical Center, University of Utah, Salt Lake City, Utah
    • ,
  • William E. Kraus, MD, FACC

      Affiliations

    • Department of Medicine and Cardiology, Duke University Medical Center, Durham, North Carolina

Received 7 February 2008 ,Revised 29 April 2008 ,Accepted 5 May 2008.

  • Image Result

    Kaplan-Meier Survival Curves

    Kaplan-Meier curves showing the percent transplant-free survival for subjects over time (in days) for single-nucleotide polymorphisms tested. (A) ADRB1-49. (B) ADRB1-389. (

    Kaplan-Meier Survival Curves

    Kaplan-Meier curves showing the percent transplant-free survival for subjects over time (in days) for single-nucleotide polymorphisms tested. (A) ADRB1-49. (B) ADRB1-389. (C) ADRB2-16. (D) ADRB2-27. (E) ADRA2C-del322-325 (Caucasian). (F) ADRA2C-del322-325 (African American). Black line = homozygous major allele (0 copies minor allele); red line = heterozygous (1 copy minor allele); green line = homozygous minor allele (2 copies minor allele). Vertical tick marks on the curves represent censored subjects.

 Drs. Sehnert, Daniels, Elashoff, and Wingrove are paid employees of CardioDx, Inc. This work was funded by CardioDx, Inc.

PII: S0735-1097(08)01936-0

doi: 10.1016/j.jacc.2008.05.022

Journal of the American College of Cardiology
Volume 52, Issue 8 , Pages 644-651 , 19 August 2008

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