Journal of the American College of Cardiology
Volume 53, Issue 2 , Pages 200-206 , 13 January 2009

Endothelial Dysfunction Induced by Post-Prandial Lipemia: Complete Protection Afforded by High-Intensity Aerobic Interval Exercise

  • Gjertrud Aunet Tyldum, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Inga Ekeberg Schjerve, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Arnt Erik Tjønna, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Idar Kirkeby-Garstad, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Department of Cardiothoracic Surgery, St. Olav's University Hospital, Trondheim, Norway
    • ,
  • Tomas O. Stølen, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Russell S. Richardson, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Department of Medicine, University of California, San Diego, La Jolla, California
    • Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah
    • Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah
    • Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah
    • ,
  • Ulrik Wisløff, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Corresponding Author InformationReprint requests and correspondence: Dr. Ulrik Wisløff, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Medical Technology Research Centre, Olav Kyrres Gate 3, N-7489 Trondheim, Norway

Received 4 June 2008 ,Revised 11 September 2008 ,Accepted 12 September 2008.

  • Image Result

    Endothelial Function

    (A) Average peak velocity and brachial diameter during the control (no exercise), continuous moderate-intensity exercise (CME), high-intensity aerobic interval exercise (HIIE), and

    Endothelial Function

    (A) Average peak velocity and brachial diameter during the control (no exercise), continuous moderate-intensity exercise (CME), high-intensity aerobic interval exercise (HIIE), and sublingual glycerol trinitrate (NTG) trials. Baseline-1 is measured before the intervention, baseline-2 16 to 18 h after intervention and immediately before the meal. Thereafter, flow-mediated dilation (FMD)/artery diameter and blood flow were measured 30 min, 2 h, and 4 h after food intake. (B) FMD of the brachial artery during the experiment. (C) FMD normalized for share rate. #Different from baseline-1, p < 0.01; *different from moderate and control, p < 0.01; **different from moderate and control, p < 0.001; §different from control, p < 0.01; £different from baseline, p < 0.05. Ex = exercise.

  • Image Result
    TAS and Endothelial Function(A) Total antioxidant status (TAS) during the control (no exercise), CME, and HIIE trials. (B) Correlation between plasma total antioxidant status and FMD in the brachial a

    TAS and Endothelial Function

    (A) Total antioxidant status (TAS) during the control (no exercise), CME, and HIIE trials. (B) Correlation between plasma total antioxidant status and FMD in the brachial artery. #Different from baseline-1, p < 0.01; *different from moderate and control, p < 0.01; §different from control, p < 0.01; †different from control, p < 0.05; £different from baseline, p < 0.05. Abbreviations as in Figure 1.

  • Image Result
    Effects of Acute Exercise and Food Ingestion(A) Glucose; (B) C-peptide; (C) triglycerides; (D) high-density lipoproteins. As there was no difference in these variables across trials, the data have bee

    Effects of Acute Exercise and Food Ingestion

    (A) Glucose; (B) C-peptide; (C) triglycerides; (D) high-density lipoproteins. As there was no difference in these variables across trials, the data have been pooled. £Different from baseline, p < 0.05; #different from baseline-1, p < 0.01.

 Steven E. Nissen, MD, MACC, served as Guest Editor for this article.

PII: S0735-1097(08)03374-3

doi: 10.1016/j.jacc.2008.09.033

Journal of the American College of Cardiology
Volume 53, Issue 2 , Pages 200-206 , 13 January 2009

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