Journal of the American College of Cardiology
Volume 53, Issue 2 , Pages 200-206 , 13 January 2009

Endothelial Dysfunction Induced by Post-Prandial Lipemia: Complete Protection Afforded by High-Intensity Aerobic Interval Exercise

  • Gjertrud Aunet Tyldum, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Inga Ekeberg Schjerve, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Arnt Erik Tjønna, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Idar Kirkeby-Garstad, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Department of Cardiothoracic Surgery, St. Olav's University Hospital, Trondheim, Norway
    • ,
  • Tomas O. Stølen, MSc

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • ,
  • Russell S. Richardson, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Department of Medicine, University of California, San Diego, La Jolla, California
    • Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah
    • Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah
    • Geriatric Research Education and Clinical Center, Salt Lake City VAMC, Salt Lake City, Utah
    • ,
  • Ulrik Wisløff, PhD

      Affiliations

    • Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    • Corresponding Author InformationReprint requests and correspondence: Dr. Ulrik Wisløff, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Medical Technology Research Centre, Olav Kyrres Gate 3, N-7489 Trondheim, Norway

Received 4 June 2008 ,Revised 11 September 2008 ,Accepted 12 September 2008.

References 

  1. Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653–658
  2. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115:1285–1295
  3. Gill JM, Al-Mamari A, Ferrell WR, et al. Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. J Am Coll Cardiol. 2004;44:2375–2382
  4. Merrill JR, Holly RG, Anderson RL, Rifai N, King ME, DeMeersman R. Hyperlipemic response of young trained and untrained men after a high fat meal. Arteriosclerosis. 1989;9:217–223
  5. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. JAMA. 1997;278:1682–1686
  6. Wisloff U, Stoylen A, Loennechen JP, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115:3086–3094
  7. Bailey DM, Lawrenson L, McEneny J, et al. Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle. Free Radic Res. 2007;41:182–190
  8. Rognmo O, Hetland E, Helgerud J, Hoff J, Slordahl SA. High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehab. 2004;11:216–222
  9. Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257–265
  10. Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol. 2005;568:357–369
  11. Gill JM, Hardman AE. Exercise and postprandial lipid metabolism: an update on potential mechanisms and interactions with high-carbohydrate diets (review). J Nutr Biochem. 2003;14:122–132
  12. Bailey DM, Davies B, Young IS, et al. EPR spectroscopic evidence of free radical outflow from an isolated muscle bed in exercising humans: functional significance of decreasing intracellular PO2 vs. increasing O2 flux. Adv Exp Med Biol. 2003;540:297–303
  13. Bailey DM, Young IS, McEneny J, et al. Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol. 2004;287:H1689–H1699
  14. Bejma J, Ji LL. Aging and acute exercise enhance free radical generation in rat skeletal muscle. J Appl Physiol. 1999;87:465–470
  15. Haram PM, Adams V, Kemi OJ, et al. Time-course of endothelial adaptation following acute and regular exercise. Eur J Cardiovasc Prev Rehab. 2006;13:585–591
  16. Ji LL. Exercise-induced modulation of antioxidant defense. Ann N Y Acad Sci. 2002;959:82–92
  17. Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP. A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation. Clin Sci (Lond). 2006;110:387–392
  18. Padilla J, Harris RA, Fly AD, Rink LD, Wallace JP. The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol. 2006;98:256–262
  19. Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol. 1997;79:350–354
  20. Cicha I, Suzuki Y, Tateishi N, Maeda N. Enhancement of red blood cell aggregation by plasma triglycerides. Clin Hemorheol Microcirc. 2001;24:247–255
  21. Westphal S, Taneva E, Kastner S, et al. Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal. Atherosclerosis. 2006;185:313–319

 Steven E. Nissen, MD, MACC, served as Guest Editor for this article.

PII: S0735-1097(08)03374-3

doi: 10.1016/j.jacc.2008.09.033

Journal of the American College of Cardiology
Volume 53, Issue 2 , Pages 200-206 , 13 January 2009

Article Tools

* Image Usage & Resolution